Invasive breast cancer and breast cancer death after non-screen detected ductal carcinoma in situ from 1990 to 2018 in England: population based cohort study

This study evaluates the long term risk of invasive breast cancer and breast cancer related death following non-screen detected DCIS diagnosis. This risk was compared to the general population and to women diagnosed with screen detected DCIS. The study utilised data from the National Disease Registration Service which identified 27543 women diagnosed with non-screen detected DCIS (1990-2018). By the end of 2018, 3651 of the study cohort developed invasive breast cancer, more than 4 times higher than the national cancer incidence rates. The 25 year cumulative invasive breast cancer risk ranged from 27.3% for <45 years old to 20.8% for 60-70 years old. 908 women died from breast cancer, almost 4 times more than expected from breast cancer death rates in general population. The 25 year cumulative risk of breast cancer death rate ranged from 7.6% for <45 years old to 6.2% for 60-70 years old. For 22753 women with unilateral DCIS treated with surgery, patients receiving mastectomy had lower 25 year cumulative rate of ipsilateral invasive breast cancer than BCS (8.2% mastectomy, 19.8% BCS +RT, and 20.6% BCS with no RT). However, 25 year breast cancer related death rates were similar in all three groups (6.5% mastectomy, 8.6% BCS + RT, and 7.8% BCS with no RT).

Classifications: Breast Cancer Treatment

Keywords: DCIS Symptomatic Invasive Breast Cancer